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g. 2004. A patient may be less responsive to antipsychotic treatment during successive episodes or exacerbations, so that residual symptoms remain as well as decrements in the patients functional capacities. 001). Submitted. These properties make them ideally suited for their role as a co- incidence detector underlying Hebbian processes in On line plasticity such as learning, chronic pain, drug tolerance and dependence (Collingridge and Singer 1990; Trujillo and Akil 1995; Danysz and Parsons 1995; Collingridge and Tdaagra 1995; Dickenson 1997).
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